The usual dosage is 5 granules, 3 times a day. Follow your doctor's instructions. The granules should be allowed to dissolve under the tongue. They can be dissolved in a little water to make them easier for children under 6 years old to take. Take Hamamelis Compound between meals and, preferably, before consuming coffee, mint, or tobacco. To use the tube, invert and twist the cap to dispense the granules. If possible, place them in a small container or, at the very least, avoid holding them in the palm of your hand.