Reserved for adults and children over 50 kg: 1 to 3 tablets of 1 g or 3 g per day to be swallowed with a glass of water, respecting an interval of at least 4 hours between each dose and in case more intense pain or fever, it can be increased to 4 g per day.
In adults weighing less than 50 kg, or in cases of mild to moderate hepatic impairment, chronic alcoholism or chronic malnutrition (low stores of hepatic glutathione) and dehydration, the maximum daily dose should not exceed 3 g. In the event of severe renal insufficiency (creatinine clearance less than 10 ml/min), the interval between 2 doses will be at least 8 hours.