Synvisc One - Intra-articular injection - Knee osteoarthritis - 6ml

- Do not use Hylane GF 20 if the packaging is open or damaged.
- The contents of the syringe must be used immediately after opening the packaging.
- Aspirate the synovial fluid or any effusion before each injection of Hylane GF 20.
- Inject Synvisc at room temperature.
- To remove the syringe from the thermoformed case (or tray), grasp it by the body without touching the piston rod.
- Inject Synvisc using strict aseptic techniques and paying particular attention to removing the cap at the end of the syringe.
- Unscrew the grey cap at the end of the syringe before removing it to minimize product leakage.
- Use a needle of appropriate diameter.
- Use a needle of appropriate length, depending on the joint
Synvisc-One: 18 to 20 gauges.
- To ensure a tight connection and prevent any leakage during administration, securely attach the needle to the Luer-type clamp on the syringe.
- Do not tighten or apply excessive pressure to fix the needle or remove its sheath, as this may break the tip of the syringe.
- Inject only into the synovial space, performing the operation, if necessary, under fluoroscopic guidance, particularly in the case of treatment of the hip and shoulder joints.
The contents of the syringe are for single use only. As indicated in the dosage instructions, inject the entire volume of the syringe (2 ml for Synvisc and 6 ml for Synvisc-One). Discard any unused Synvisc/Synvisc-One product.
- When working under fluoroscopic guidance, an ionic or non-ionic contrast agent may be used. Do not use more than 1 ml of contrast agent per 2 ml of Hylane GF 20.
- Do not sterilize Hylane GF 20 again.

Indications for a Synvisc One injection
Synvisc One by intra-articular injection is indicated for osteoarthritis of the knee. It can be administered at all stages of the joint condition.
It proves to be more effective in patients who regularly mobilize the affected joint.
Generally, a single injection is recommended. A second injection is possible 6 months later if symptoms persist.

Precautions for use of Synvisc One
Synvisc One injection is contraindicated in cases of venous or lymphatic stasis in the limb or the affected joint, as well as in cases of infection or inflammation at the joint site.
Do not inject intravascularly or outside the joint cavity.
Do not use disinfectants containing quaternary ammonium salts (risk of product precipitation).
Following the injection, it is recommended to rest for a few days and avoid any intense physical activity.
In some cases, the injection of Synvisc One may cause localized minor pain, slight swelling with a sensation of heat and redness.
Synvis One contains hyaluronic acid derived from avian sources. Patients should be informed of this, and it should not be used by individuals with an allergy to avian proteins.

Per 1 ml (Hylane GF 20):
hylan 8.0 mg, sodium chloride 8.5 mg,
disodium phosphate 0.16 mg,
hydrated monosodium phosphate 0.04 mg,
water for injectable preparations qs.
Synvisc-One contains 6 ml of Hylane GF 20.